THIOCOUMARINS: FROM THE SYNTHESIS TO THE BIOLOGICAL APPLICATIONS

Thiocoumarins: From the Synthesis to the Biological Applications

Gameboy Advance Link Cable Coumarin is a privilege scaffold in medicinal chemistry.Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants.Thiocoumarins are a particular class of coumarins in which one or two of the oxygen atoms are replaced by a sulfur.The

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SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Epigenetic regulators play a critical role in normal and malignant hematopoiesis.Deregulation, including epigenetic deregulation, of the HOXA gene cluster drives transformation of about 50% of acute myeloid leukemia.We recently showed that the Histone 3 Lysine 9 methyltransferase SETDB1 negatively regulates the expression of the pro-leukemic genes

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Spatial quantile regression in analysis of mortality

Hand Care Set The paper concerns mortality in Poland.The aim of the article is to identify factors determining average life length of men and women in 66 subregions of Poland.We use spatial quantile regression methodology which allows studying dependencies between variables in different quantiles of the response distribution.Moreover, this statisti

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Use of lactoferrin supplement as an efficient antioxidant to ameliorate the effects of mercury-induced oxidative stress in male wistar rats

Background: The present study was carried out to test the antioxidant activity of lactoferrin as a dietary supplement to alleviate the effects of oxidative stress induced by mercury toxicity.Hematological and biochemical assays were employed to evaluate the ameliorating effects of lactoferrin.Methods: Sixty male Wistar rats were allotted randomly a

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